Another Major Investment in Deuterium Technology for Pharmaceuticals

First Auspex Pharmaceuticals announces its IPO priced at $12.00 per share, and now Concert Pharmaceuticals announces its IPO at $14.00 per share.  Auspex and Concert are both working on developing drugs containing deuterium (H2) in place of protium (H1) at key positions.  Both companies have pharma products in the pipeline and both have products that are in mid-phase trials.  Concert has made a number of collaboration agreements with companies to utilize deuterium substitution in pharmaceuticals already on the market.  The principle behind the technology is that deuterium binds more tightly than protium and therefore is less reactive.  Substitution of protium with deuterium in a pharmaceutical is expected to reduce the rate at which the drug is metabolized, thereby allowing a more convenient and safer therapy regimen. The steady pattern of major investment leading to IPOs for both companies supports the confidence that investors have in the ultimate success of this deuterium substitution technology. Contact us as your supplier of deuterium gas for sale.

View the article in Xconomy:

Major Investment in Technology for Pharmaceuticals

Auspex Pharmaceuticals Inc has raised $35 million which will advance the clinical trials of its deuterium substituted drug SD-809 designed for the treatment of chorea associated with Huntington’s disease.  In addition, the company has appointed an industry veteran, Gerald Proehl, to its Board of Directors says the article in Digital Journal. Auspex has a pipeline of drugs using deuterium substitution in order to lower the rate of breakdown of the active metabolites. While deuterium reduces the breakdown of the active metabolite of the drug, there is no effect on the target or receptor binding of the drug. It is expected that these features will result in a more convenient and safer dosage regimen, separation of pharmacological effects and a number of other benefits. This is another example of investors recognizing the growing importance of deuterium and deuterium oxide in pharmaceutical applications. For more current up to date of our deuterium gas price list click here.

For more information on Auspex

To view the article in Digital Journal

Toshiba Makes a Large Advance in Semi-Conductor Fabrication

The growing use of deuterium in the high tech sector has again been demonstrated. In a news release by PR Newswire, Toshiba has announced a major breakthrough in the fabrication of low-power semiconductors.  The new technology reduces the stress induced leakage current – the enemy of power efficiency – by at least 30%.  The process uses deuterium gas, burning the gas in ambient oxygen during the gate oxidation process.  This introduces deuterium atoms into the gate oxide.  Introduction of SiD4 into the process increased deuterium in the SiO­2 layer by a factor of ten. The new process can also be applied to achieve higher reliability in thin-tunnel oxides for non-volatile memories. Find more information on d2o benefits click here

The link to the press release is given below.

Labeling for Mass Spec analysis

This article is one of an ‘Expert Tips’ series from Waters, and it has useful recommendations for deuterium labelling of peptides for protein structural dynamics and conformational changes.  Deuterium oxide is used to label proteins for specific times and analysis performed by mass spectroscopy with appropriate software.  This is an example of the applications of deuterium oxide in pharmaceutical and biological research.  This article written by Dr. Joomi Ahn has been published in Genetic Engineering & Biotechnology News. For more up to date information on deuterium oxide for sale click here.

Will India need to import heavy water?

India has perhaps the world’s most advanced nuclear energy program.  The nation has some 20 reactors now (90% of which are heavy water moderated types) and plans to add approximately 60,000 MW of new nuclear energy generation by 2032.  Heavy water reactors will remain a significant portion of the planned role out.  In addition to four more heavy water reactors coming on stream in 2015 and 2016, the attached article outlines India’s near term plan of adding 16 heavy water reactors and notes that these reactors are demonstrated to be highly economical and reliable.  This many reactors will require a tremendous amount of deuterium oxide (heavy water) which could be substantially higher than India’s current ability to supply. For more information on deuterium oxide uses click thru to page.

The benefits of deuterium in building a better microchip

Here is an interesting link about Samsung’s activities to make a better microchip through use of deuterium (heavy hydrogen).  The core technology was discovered at the University of Illinois University in the late 1990s and since 2010 it has been progressing towards commercialization.  Deuterium has superior properties to regular hydrogen and allow chips to run hotter and faster for similar life times. Cell phones and computers are made better through use of deuterium made from deuterium oxide. Contact us for more information on deuterium supplier

Life science applications with living cells

One of the many examples of innovation based on deuterium’s role in non-radioactive life science applications is with living cells.  A technique uses the fact a carbon-deuterium bond vibrates at a unique frequency different from the normal carbon-hydrogen bond to support research into protein development inside the brain as long-term memory is formed.

To answer your question like “What is deuterium?” click thru for more information.